Aaptamine
Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner. Aaptamine is a competitive antagonist of alpha-adrenoceptors in vascular smooth muscles.
Aaptamine has potent cytotoxicity that may be explained by its ability to intercalate DNA, it exerts an antiproliferative effect against NT2-R, a cisplatin-resistant subline of the human embryonal carcinoma cell line NT2. Aaptamine shows anti-photoaging effect in UVB-irradiated human dermal fibroblasts and epidermal keratinocytes. Aaptamine also has anti-antiviral activity.
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:
Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month
If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles.
Storage conditions for some special products should refer to their COAs.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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