Beta-Hydroxyisovalerylshikonin | CAS 7415-78-3

Beta-Hydroxyisovalerylshikonin is an ATP non-competitive inhibitor of protein-tyrosine kinases such as v-Src and EGFR, and has been shown to induce apoptosis in several human tumor cell lines. Beta-Hydroxyisovalerylshikonin has anti-adipogenic, antiinflammatory and antitumor effects, it activated AMPK, which was followed by the downregulation of mature SREBP‑1c and fat-forming enzymes, leading to the inhibition of adipogenesis. Beta-Hydroxyisovalerylshikonin can significantly decrease viability of HCT116 cells (IC50 values of 30.9 ug/mL).

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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:

Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month

If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their COAs.

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Product Name	Beta-Hydroxyisovalerylshikonin
CAS No.:	7415-78-3
Catalog No.:	CFN93028
Molecular Formula:	C₂₁H₂₄O₇
Molecular Weight:	388.42 g/mol
Purity:	>=98%
Type of Compound:	Quinones
Physical Desc.:	Solid
Source:	The roots of Lithosperraum erythrorhizon Sieb. et Zucc.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
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