Diammonium glycyrrhizinate
Diammonium glycyrrhizinate shows antiviral, and anti-inflammatory effects, it can reduce inflammatory injury in a rat model of ulcerative colitis, this may occur via suppression of NF-kappaB, TNF-alpha and ICAM-1 in colonic mucosa. Diammonium glycyrrhizinate may possibly protect the liver from injury via two pathways: direct protection of hepatocytes from apoptosis through an IL-6-dependent way and indirect inhibition of T-cell-mediated inflammation through an IL-10-dependent way.
Diammonium glycyrrhizinate exerts potential beneficial effects on Alzheimer's disease, it can attenuate Aβ(1-42)-induced neuronal injury by preventing mitochondrial dysfunction and oxidative stress and improve cognitive impairment in Aβ(1-42)-induced AD mice.
Diammonium glycyrrhizinate also can inhibit airway smooth muscle proliferation possibly through up- regulation of PPARγ in a murine model of chronic asthma.
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:
Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month
If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles.
Storage conditions for some special products should refer to their COAs.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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