Glabrol
Glabrol is a PTP1B inhibitor, it is also a CYP1B1 inhibitor, it shows inhibition of CYP1B1 in live cell assay with the IC50 value of 15 uM. Glabrol has hypnotic effects, it induces sleep via a positive allosteric modulation of GABA(A)-BZD receptors. Glabrol possesses significant antimicrobial activity in vitro. Glabrol may have potential therapy for the treatment in obesity and type 2 diabetes patients, it shows a noncompetitive type of inhibition against diacylglycerol acyltransferase (DGAT) with an IC50 value of 8.0 microM.
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:
Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month
If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles.
Storage conditions for some special products should refer to their COAs.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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