Limonin
Limonin is a widely used dietary supplement, one of the most prevalent citrus limonoids, which has antioxidant, anti-inflammatory, anticancer and anti-human immunodeficiency virus(HIV)activity. It induced a down regulation of TLR-2 ,TLR-4,TNF-α, TNF-α/IL-10,NF-κB and caspase. It showed the potent inhibition of CYP3A4, with IC50 values of 6.20 μM (CYP3A4/testosterone) and 19.10 μM (CYP3A4/midazolam).
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:
Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month
If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles.
Storage conditions for some special products should refer to their COAs.
Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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