Nordihydroguaiaretic acid

Nordihydroguaiaretic acid
Product Name Nordihydroguaiaretic acid
CAS No.: 500-38-9
Catalog No.: CFN70384
Molecular Formula: C18H22O4
Molecular Weight: 302.4 g/mol
Purity: >=98%
Type of Compound: Lignans
Physical Desc.: Powder
Source: The herbs of Larrea divaricata
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Price: $50/20mg
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Nordihydroguaiaretic acid(NDGA), an inhibitor of lipoxygenase, also inhibits cytochrome P-450-mediated monooxygenase activity in rat epidermal and hepatic microsomes. NDGA has anti-inflammatory, antimutagen and/or anticarcinogen activities. NDGA protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation, it can interupt a neurodegenerative pathway relevant to the pathophysiology of Alzheimer's disease. NDGA protects against high-fat diet-induced fatty liver by activating AMP-activated protein kinase in obese mice. NDGA-crosslinking of decellularized valvular matrix is a promising approach for preparation of heart valve tissue engineering scaffolds.
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:

Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month

If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their COAs.

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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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