Retrorsine
Retrorsine selectively inhibits hepatocyte proliferation and following liver injury evokes small hepatocyte-like progenitor cells.OCT1 mediates the liver-specific uptake of Retrorsine, and plays an important role in Retrorsine-induced hepatotoxicity together with CYP3A4. Consequently, the OCT1 inhibitors could be applied to protect the liver from the toxicity of Retrorsine.
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Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:
Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month
If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles.
Storage conditions for some special products should refer to their COAs.
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The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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