Stevenleaf | CAS 80321-63-7

1. Gypenosides (Gyp, Stevenleaf) induce apoptosis in human hepatoma cells through the up-regulation of Bax and Bak, and down-regulation of Bcl-2, release of mitochondrial cytochrome c and activation of caspase cascade.
2. Gypenosides induce ER stress and production of reactive oxygen species and Ca 2+ , change the ratio of Bcl-2 and Bax, followed by the dysfunction of mitochondria, cause cytochrome c release, activation of caspase-3 before leading to apoptosis, these results provide information towards an understanding of the mechanisms by which Gyp induces cell cycle arrest and apoptosis in human tongue cancer cells.
3. Gypenosides can inhibit invasion and migration of human tongue SCC4 cells by down-regulating proteins associated with these processes, resulting in reduced metastasis.
4. Gypenosides imply their remarkable preventative and therapeutic potential in treatment of neurological diseases involving glutamate and oxidative stress.
5. The extensive antioxidant effect of gypenosides may be valuable to the prevention and treatment of various diseases such as atherosclerosis, liver disease and inflammation.

Inquire / Order: manager@chemfaces.com
Technical Inquiries: service@chemfaces.com
Tel: +86-27-84237783
Fax: +86-27-84254680

Address:
1 Building, No. 176, CheCheng West Rd., Wuhan Economic and Technological Development Zone, Wuhan, Hubei 430056, PRC

Recommended storage conditions and precautions regarding proper product handling are contained in the product Certificate of Analysis (COA). Here are general storage guidelines for compounds:

Powder: -20°C 3 years and 4°C 2 years
In solvent: -80°C 6 months and -20°C 1 month

If the solution is stored at -20°C for more than one month, it should be re-examined to ensure its efficacy. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their COAs.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Stevenleaf
CAS No.:	80321-63-7
Catalog No.:	CFN99189
Molecular Formula:	C₄₇H₈₀O₁₇
Molecular Weight:	917.2 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	White powder
Source:	The herb of Gynostemma pentaphyllum (Thunb.) Makino
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Price:

Name:	*
E-mail:	*
Expected:	I would like to request a price quotation for Stevenleaf. Do you have a bulk discount? I want to order the Stevenleaf, Would you please let me know a distributor in local. I would like to purchase of Stevenleaf, Is it purchasable? if possible, Could you give me more information for price, amount, and delivery time.
Message:	*
CheckCode:
	* Welcome to our website. If you have any questions, please send a message to us. We'll do our best to get back to you within 24 hours.